Doppler-exclusive
diagnostic, monitoring & predictive frameworks
for hemodynamics
Unprecedented quantification of many hemodynamic metrics
and doing it
NON-INVASIVELY
Ventricular pressure-volume loop (PV loop) and other heart function metrics can elucidate etiology of failure of TAVR and interventions
![](https://motamedlab.com/wp-content/uploads/2024/05/Figure2W1400.png)
Diagnostic, monitoring, and predictive tool for subjects with complex valvular, vascular and ventricular diseases
and their interventions
![](https://motamedlab.com/wp-content/uploads/2024/05/Picture1.gif)
LV workload: 1.8J
Normalized LV workload (Workload/SV): 21.7 mJ/mL
Systemic Arterial Compliance: 1.87 mL/mmHg
Max LV pressure: 224.4 mmHg
Max Aortic pressure: 125.5 mmHg
![](https://motamedlab.com/wp-content/uploads/2024/05/Picture2-1.gif)
End diastolic pressure (EDP): 12.2 mmHg
End diastolic volume (EDV): 125.6 mL
End systolic pressure (ESP): 202.8 mmHg
End systolic volume (ESV): 44.5 mL
Diagnostic, monitoring, and predictive tool for patients with obstructive cardiomyopathy
Example quantification in one patient with obstructive cardiomyopathy
- Obstructive cardiomyopathy (BSA: 1.88 m2)
- Cardiovascular comorbidities: High BP; Dyslipemia, Gastritis
- No aortic regurgitation; Moderate mitral regurgitation
- Aortic valve effective orifice area: 0.83 cm2
- Blood pressure: 145/76 mmHg
- CW aortic- peak velocity with valsalva: 5.5 m/s; Peak gradient: 121 mmHg
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p1-e1717163253560.png)
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p2.png)
Flow obstruction and turbulent flow due to the left ventricle hypertrophy
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p3-e1717276507924.png)
Severe obstructive cardiomyopathy
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p4Marked-e1717195848940.png)
Mitral valve anterior leaflet is in contact with the left ventricle wall during diastole
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p5Marked-e1717276474420.png)
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p3-e1717276507924.png)
Severe obstructive cardiomyopathy
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p4Marked-e1717195848940.png)
Mitral valve anterior leaflet is in contact with the left ventricle wall during diastole
![](https://motamedlab.com/wp-content/uploads/2024/05/Patient8_p5Marked-e1717276474420.png)
![](https://motamedlab.com/wp-content/uploads/2024/06/Patient8_p6.png)
LV workload: 2.74 J
Normalized LV workload (to forward stroke volume) : 27.1 mJ/mL
End diastolic pressure (EDP): 33.5 mmHg
End diastole volume (EDV): 164.5 mL
End systole pressure (ESP): 165 mmHg
End systole volume (ESV): 21.7 mL
![](https://motamedlab.com/wp-content/uploads/2024/06/Patient8_p7.png)
SAC : 0.41 mL/mmHg
Max LV pressure: 183.5 mmHg
Max LA pressure: 31.4 mmHg
![](https://motamedlab.com/wp-content/uploads/2024/06/Patient8_p8.png)
Diastole filling pattern
Peak E wave velocity ~ 70 cm/s
Peak A wave velocity ~ 105 cm/s
E/A ratio ~ 0.66 (normal range : 0.75 – 1.5)
Deceleration time ~ 237 ms (normal range 160 – 260 ms)
![](https://motamedlab.com/wp-content/uploads/2024/06/Patient8_p9.png)
Peak e’ wave velocity ~ 3 cm/s
Peak a’ wave velocity ~ 8 cm/s
E/e’ ratio ~ 23.3 (normal range < 15) (Estimation of LVEDP)